A leader in targeted epigenetic drug discovery and development for improved therapeutic outcomes.
‘This program increases our broadening pipeline of targeted epigenetic medicines and is another example of the wide array of human disease indications that selective HDAC inhibitors hold guarantee.’ Related StoriesSingle gene variation may impact obesity in kids, adultsScalable production of gene therapy vectors: an interview with Frank UbagsPerisylvian polymicrogyria gene found The induction of HbF can be an established therapeutic strategy for SCD and could potentially also be a highly effective therapeutic strategy for bT. Previous studies suggested that non-specific HDAC inhibitors were effective in inducing HbF, nevertheless, their advancement has been delayed because of concerns over variable efficacy and off-target side-effects. Acetylon scientific founders James E. Bradner, MD, and Ralph Mazitschek, Ph.D., of Harvard Medical School first demonstrated the prospect of selective HDAC1/2 inhibition in inducing HbF .‘Paracetamol poisoning can be an extremely critical overdose which, if not timely and treated accurately, can be life-threatening,’ stated Dr. Mal Eutick, Chief and President Executive Officer of Phebra. ‘We are very happy to bring in Acetadote to the Australian medical community as a significant treatment alternative to other obtainable therapies.’ Acetadote, which has been available in the United States since Cumberland’s 2004 introduction of the product, can be used in hospital crisis departments to prevent or lessen potential liver harm caused by an overdose of acetaminophen, a common ingredient in lots of over-the-counter pain fever-reducing and relief products. Related StoriesBoston Children's Medical center selects Vijay G.