ATSP-7041 stapled peptide activates p53.

Key findings from the paper demonstrated that ATSP 7041: suppressed tumor growth in pet models of multiple human xenograft models, including breast bone and cancer cancer can be an equipotent dual inhibitor of MDM2 and MDMX that restores p53 specific activity is a peptide that efficiently penetrated cell membranes and exhibited a far more durable on mechanism effect on p53 signaling than small-molecule MDM2-selective inhibitors exhibited favorable drug-like and pharmacokinetic properties that may support convenient medical dosing regimens [including the potential for once-weekly dosing].. ATSP-7041 stapled peptide activates p53, suppresses tumor growth in animal models Aileron Therapeutics, Inc., a clinical stage biopharmaceutical firm that’s developing first-in-class therapeutics predicated on its proprietary Stapled Peptide medication platform, announced today the publication of preclinical data on ATSP-7041, a potent and selective stapled peptide re-activator of the wild type p53 tumor suppressor protein.

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