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Cincinnati Children’s researchers publish positive results from clinical trial Investigational Treatment for Debilitating allergic diseaseCincinnati Children Hospital Medical Center, a recognized leader in pediatric research dedicated to changing the outcomes for children, today announced the publication of positive results from a Phase 1 / 2 clinical trial mepolizumab, a humanized antibody to interleukin 5 , for the treatment of eosinophilic esophagitis . EE is an allergic inflammatory response caused by the accumulation of large numbers of eosinophils characterized the esophagus, the esophagus, to vomiting and difficulty swallowing. – ‘Previous results suggested an important role for interleukin-5, in the accumulation of eosinophils in the esophagus and provided a strong rationale for the evaluation of anti – IL5 antibody as a potential therapy for EE,’said Marc Rothenberg, MD, Director of the Department for Allergy and Immunology at Cincinnati Children’s Hospital Medical College. ‘With the support of the CCHMC Translational Research Office provided this study provides a strong proof of concept for the use of mepolizumab. These data the pharmaceutical industry has fueled this clinical experience with the aim of patient to extend with a meaningful and effective treatment option. ‘That paper, was published in the December issue of the Journal of Allergy and Immunology, describes positive results from an open-label phase I / 2 study evaluating the safety and efficacy of mepolizumab in four adult patients with EE, had the long-term swallowing problems and esophageal stricture caused by chronic inflammation. Patients received 3 monthly infusions mepolizumab without change in their current therapy and were followed for 28 weeks.
##The Environmental Health Sciences Center at the University of Rochester who will partial National Institute for National Institute of Environmental Health Sciences supported the research. In addition, the University of Rochester have a patent for the identification of a new chemical target to protect stored handle the progress of the COPD and emphysema by means of induction of the gene Sirtuin1.
Some 23 million Americans COPD, the inflammatory induced the progressive dyspnea 2020 will are expected to to be the third most frequent killer worldwide, now least 9 % the elderly is appreciated that suffer from from debilitating lung disorders.